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Methaqualone, sold under the brand name Quaalude in the US and Mandrax in the UK,Australia and South Africa, is a sedative and hypnotic medication. It is a member of the Quinazolinone class.

The sedative hypnotic activity of methaqualone was first noted by researchers in the 1950s. In 1962, methaqualone was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant.

Methaqualone became increasingly popular as a recreational drug and club drug in the late 1960s and 1970s, known variously as “ludes” or “sopers” (also “soaps”) in the U.S. and “mandrakes” and “mandies” in the UK, Australia and New Zealand. The drug was often used by hippies and by people who went dancing at glam rock clubs in the 1970s and at discos. The drug was so popular in the disco scene of the 1970s that the drug, sold under the brand name Quaaludes, was nicknamed disco biscuits. Buy Quaaludes Powder online.

Medical use

Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system, similarly to benzodiazepines and barbiturates. When GABA activity is increased, blood pressure drops and breathing and pulse rates slow, leading to a state of deep relaxation. These properties explain why methaqualone was originally mainly prescribed for insomnia.[2]

Methaqualone was not recommended for use while pregnant and is in pregnancy category D.[3]

Overdose

An overdose can lead to nervous system shutdown, coma and death.[4] Additional effects are delirium, convulsions, hypertonia, hyperreflexia, vomiting, kidney failure, coma, and death through cardiac or respiratory arrest. It resembles barbiturate poisoning, but with increased motor difficulties and a lower incidence of cardiac or respiratory depression. The standard single tablet adult dose of Quaalude brand of methaqualone was 300 mg when made by Lemmon. A dose of 8000 mg is lethal and a dose as little as 200 mg could induce a coma if taken with an alcoholic beverage.[5

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